COMPARATIVE EVALUATION OF THE ANTIHYPERTENSIVE EFFICACY OF AMLODIPINE AND KC-4 POLYPHENOL IN AN ADRENALINE-INDUCED EXPERIMENTAL HYPERTENSION MODEL
Keywords:
adrenaline, antihypertensive, aortic blood vessel, polyphenol, verapamil, Ca2+ channel, contraction force.Abstract
This study comparatively evaluated the antihypertensive and vasorelaxant properties of the synthetic compound KC-4 and amlodipine, a standard L-type Ca2+ channel blocker. The pharmacological activity of KC-4 was investigated using complementary in vivo, in silico, and ex vivo approaches. This integrated design makes it possible to characterize, in a connected manner, the compound’s effects on arterial blood pressure in a living organism, its potential molecular targets, and its direct functional efficacy in isolated blood vessels.
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