DIAGNOSTIC SIGNIFICANCE OF HEMATOMORPHOLOGICAL AND IMMUNOPHENOTYPIC CHARACTERISTICS OF ACUTE MYELOID LEUKEMIA IN CHILDREN

Abstract

One of the most pressing challenges in pediatric oncohematology is the group of neoplastic disorders of the hematopoietic system, among which acute myeloid leukemia (AML) plays a central role. AML is characterized by clonal proliferation of myeloid precursor cells in the bone marrow, accompanied by a blockade of normal differentiation. This disease accounts for 15–20% of all childhood leukemias. Its rapid clinical progression necessitates a thorough understanding of both morphological and immunophenotypic properties of leukemic blasts, which are essential for accurate diagnosis and prognosis determination.