CLINICAL COURSE AND DIAGNOSTIC APPROACHES OF ACUTE PANCREATITIS
Keywords:
acute pancreatitis, pancreatic inflammation, diagnostic approaches, clinical course, serum amylase, serum lipase, computed tomography, magnetic resonance imaging, ultrasonography, endoscopic diagnosis, gallstones, alcohol-related pancreatitis, pancreatic disorders, prognosis, complications, inflammatory diseases.Abstract
This article discusses the clinical course and diagnostic approaches of acute pancreatitis, an inflammatory condition of the pancreas that can range from mild self-limiting disease to severe life-threatening complications. The study examines the etiology, pathophysiology, clinical manifestations, and progression of acute pancreatitis, with particular attention to common causes such as gallstones, alcohol abuse, metabolic disorders, and infections. The article highlights the importance of early diagnosis and accurate assessment of disease severity in improving patient outcomes. Diagnostic methods including clinical evaluation, laboratory investigations, serum amylase and lipase measurements, ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic techniques are analyzed. Furthermore, the paper explores current classification systems and prognostic criteria used in clinical practice. The findings emphasize that timely diagnosis and appropriate management are essential for reducing complications, mortality, and improving the quality of patient care.
References
1. Banks, P. A., Bollen, T. L., Dervenis, C., et al. (2013). Classification of acute pancreatitis—2012: Revision of the Atlanta classification and definitions by international consensus. Gut, 62(1), 102–111. https://doi.org/10.1136/gutjnl-2012-302779
2. Sarr, M. G., Banks, P. A., Bollen, T. L., et al. (2013). The new revised classification of acute pancreatitis 2012. Surgical Clinics of North America, 93(3), 549–562. https://doi.org/10.1016/j.suc.2013.02.012
3. Gao, W., Yang, H. X., & Ma, C. E. (2015). The value of BISAP score for predicting mortality and severity in acute pancreatitis: A meta-analysis. PLOS ONE, 10(6), e0130412. https://doi.org/10.1371/journal.pone.0130412
4. Banks, P. A., Bollen, T. L., Dervenis, C., Gooszen, H. G., Johnson, C. D., Sarr, M. G., Tsiotos, G. G., & Vege, S. S. (2013). Classification of acute pancreatitis—2012: Revision of the Atlanta classification and definitions by international consensus. Gut, 62(1), 102–111. https://doi.org/10.1136/gutjnl-2012-302779
5. Mederos, M. A., Reber, H. A., & Girgis, M. D. (2021). Acute pancreatitis: A review. JAMA, 325(4), 382–390. https://doi.org/10.1001/jama.2020.20317
6. Leppäniemi, A., Tolonen, M., Tarasconi, A., Segovia-Lohse, H., Gamberini, E., Kirkpatrick, A. W., et al. (2019). 2019 WSES guidelines for the management of severe acute pancreatitis. World Journal of Emergency Surgery, 14, 27. https://doi.org/10.1186/s13017-019-0247-0
7. Peery, A. F., Crockett, S. D., Murphy, C. C., Lund, J. L., Dellon, E. S., Williams, J. L., et al. (2019). Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology, 156(1), 254–272.e11. https://doi.org/10.1053/j.gastro.2018.08.063
8. Goo, D. E., Kim, Y. K., & Kim, H. J. (2020). Imaging of acute pancreatitis and its complications. Radiographics, 40(7), 1905–1926. https://doi.org/10.1148/rg.2020200015
9. Wu, B. U., Johannes, R. S., Sun, X., Tabak, Y., Conwell, D. L., & Banks, P. A. (2008). The early prediction of mortality in acute pancreatitis: A large population-based study. Gut, 57(12), 1698–1703. https://doi.org/10.1136/gut.2008.152702
10. Lankisch, P. G., Apte, M., & Banks, P. A. (2015). Acute pancreatitis. The Lancet, 386(9988), 85–96. https://doi.org/10.1016/S0140-6736(14)60649-8
11. Thoeni, R. F. (2012). The revised Atlanta classification of acute pancreatitis: Its importance for the radiologist and its effect on treatment. Radiology, 262(3), 751–764. https://doi.org/10.1148/radiol.11110947
12. Bollen, T. L., van Santvoort, H. C., Besselink, M. G., van Leeuwen, M. S., Horvath, K. D., & Gooszen, H. G. (2007). The Atlanta classification of acute pancreatitis revisited. British Journal of Surgery, 94(2), 187–194. https://doi.org/10.1002/bjs.5778
