ASSESSMENT OF THE ANTIHYPERTENSIVE EFFICACY OF AMLODIPINE, A SYNTHETIC COMPOUND, IN AN EXPERIMENTAL HYPERTENSION MODEL INDUCED BY ADRENALINE
Keywords:
adrenaline, antihypertensive, aortic blood vessel, polyphenol, verapamil, Ca2+ channel, contraction force, Ca2+ ions, smooth muscle cell.Abstract
This study comparatively evaluated the antihypertensive and vasorelaxant properties of the synthetic compound KC-4, selected as the research object, and amlodipine, a standard L-type Ca2+ channel blocker. The pharmacological activity of KC-4 was investigated using complementary in vivo, in silico, and ex vivo approaches. In the in vivo studies, the dose–response effects of KC-4 and amlodipine on systolic and diastolic blood pressure in healthy rats were assessed. In the subsequent stage, their antihypertensive efficacy was examined in an experimental hypertension model induced by adrenaline. This approach made it possible to determine the effects of KC-4 on blood pressure under physiological and pathological conditions and to select effective doses for subsequent mechanistic experiments.
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